Surprise side effects: Chrissy Metz flaunts 100-lb weight loss while gushing about GLP-1

Premiere remarks and Broadway demands

At the “Nocturne” premiere over the weekend, Metz discussed how a GLP-1 has affected her as she makes her Broadway debut in “& Juliet.” She told ET that performing eight shows a week had been a positive experience. Metz said the medication had “really minimized” her inflammation. She also mentioned perimenopause and knee issues as challenges she faces.

Less focus on food

Metz said having more mental space beyond thoughts about food had been helpful. She described the effect as “super, super helpful,” according to her comments to ET. In an earlier interview with People, Metz said she had been skeptical before trying the medication. She called the experience “great” and said she no longer obsessed over what she would eat, even while having a meal.

Strength training and weight loss

In August, Metz shared a progress report on Instagram, showing her bicep and discussing strength training. She said she was making progress and expressed affection for her body.

The article gives differing accounts of how Metz lost 100 pounds. In April 2025, she told the Daily Mail that strength training was responsible; another passage says she lost 100 pounds last year and later revealed she was taking a GLP-1.

Her view on personal choices

In April 2025, when asked about Ozempic, Metz said decisions about medication were personal. She also spoke in favor of destigmatizing such choices. Metz said people ultimately want to feel good about themselves. She previously described years of diets that did not work and reflected on having been taught to view food as bad.